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Nanoscope Therapeutics Appoints Two Pharmaceutical Industry Veterans as Scientific and Clinical Advisors

Clinical-phase biotechnology company building gene therapies to treat retinal degenerative diseases, these days introduced that Naveed Shams MD, PhD, and Thomas Ciulla MD, equally of whom have intensive executive management experience at pioneering ophthalmology firms, will provide as advisors to the Firm’s Board and Administration.

We are extremely delighted to have these distinguished leaders sign up for our team of advisors. Their deep knowledge and lengthy listing of achievements in the ophthalmology house will enjoy a key part in offering steerage to aid our scientific and corporate system. We search ahead to leveraging their experience as we advance of Nanoscope’s groundbreaking platform of optogenetic therapies, reported Nanoscope’s Co-Founder and CEO, Sulagna Bhattacharya.

By delivering light-weight-delicate molecules into retinal cells, Nanoscope is advancing a special gene remedy approach to restoring vision in men and women suffering from various inherited retinal degenerative ailments, together with Retinitis Pigmentosa (RP), Stargardt, and dry AMD, mentioned Dr. Shams. Their distinctive and innovative technique to treating blinding eye disorders and sturdy medical knowledge to day displays probable to revolutionize how we address retinal degenerative conditions and boost individual outcomes. I hope to add to the speedy advancement of this system as the Corporation completes its ongoing Section 2b research in RP and appears to fast increase into other indications.

Multi-Characteristic Opsin, or MCOs, have the prospective to handle all types of retinal degeneration and are applicable for patients struggling from complete or partial destruction to the retina, said Dr. Ciulla. Nanoscope has by now started to exhibit the incredible likely of this approach, together with amazing efficacy and good tolerability in severely visually impaired individuals. I glance ahead to functioning with their globe-class crew in seeing the opportunity of this technique absolutely elucidated in the clinic.

Dr. Shams was most recently the Chief Science Officer at ProQR Therapeutics and formerly served as President and CEO of Santen Inc, and International Head of R&D at Santen Prescribed drugs, a global ophthalmology corporation, for more than a ten years. He has more than 25 decades of global drug advancement working experience throughout start off-ups and significant multinationals, including Novartis and Genentech/Roche. At Genentech, Dr. Shams aided to build the Ophthalmic Scientific R&D Team and led the development of Lucentis® through approval. Prior to becoming a member of sector, Dr. Shams was on the School at the Section of Ophthalmology, Harvard Professional medical School. Dr. Shams holds an MD from Dow Healthcare Higher education and a PhD in microbiology/immunology from the University of South Carolina. He also done a fellowship in wound therapeutic and corneal transplantation at Harvard College.

Dr. Ciulla has 25 a long time of government management, clinical investigation and academic management practical experience. He has served as Main Healthcare Officer since 2018 and also Main Enhancement Officer given that 2020 at Clearside Biomedical, which pioneered the improvement of the to start with Fda-accepted suprachoroidal remedy (Xipere®). At Spark Therapeutics, he led health-related approach via approval and commercialization of Luxturna® (voretigene), the to start with Food and drug administration-authorized gene treatment for a hereditary retinal condition, which involved novel purposeful vision endpoints, elaborate genetic testing paradigms, and new administration procedures. Prior to Spark, he served as VP-Medical Strategy at Ophthotech (now Iveric Bio), exactly where he contributed to the structure of the thriving Period 2/3 trial of Zimura® in Geographic Atrophy (GA). He retains a BA in chemistry from Harvard University, an MD from College of California, San Francisco, Medical College and an MBA from Indiana College. He finished residency at Harvard Clinical Faculty, retina fellowship at Tufts Health-related Faculty, and is a board-licensed ophthalmologist and retina specialist.

About Nanoscope Therapeutics Inc.
Nanoscope Therapeutics is building gene-agnostic, sight restoring optogenetic therapies for the millions of people blinded by retinal degenerative ailments, for which no get rid of exists. The company’s guide asset, MCO-010, is presently in Section 2b multicenter, randomized, double-masked, sham-controlled medical trials in the U.S. for retinitis pigmentosa (NCT04945772) with best line data envisioned Q1, 2023. The business has also initiated a Section 2 demo of MCO therapy in Stargardt individuals. MCO-010 has gained Fda orphan drug designations for RP and Stargardt. The pipeline also includes therapy for GA.